| 发明名称 |
COMBINATION CANCER THERAPY USING BISPHOSPHONATES AND ANTI-EGFR AGENTS |
| 摘要 |
The present invention relates to combination therapies for the treatment of EGFR-related diseases, particularly EGFR-related cancers. This invention also relates to a method of enhancing the efficacy of an EGFR family member antagonist and therapeutic methods for subjects who are refractory to treatment with an EGFR family member antagonist. The invention also relates to pharmaceutical compositions useful for treatment of EGFR-related diseases. |
| 申请公布号 |
US2016038516(A1) |
申请公布日期 |
2016.02.11 |
| 申请号 |
US201314409136 |
申请日期 |
2013.06.25 |
| 申请人 |
Narla Goutham;Iqbal Jameel;Mone Zaidi Consulting, Inc. |
发明人 |
Zaidi Mone;Narla Goutham;Iqbal Jameel |
| 分类号 |
A61K31/675;A61K31/538;A61K45/06;A61K31/517 |
主分类号 |
A61K31/675 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of treating cancer, comprising
identifying a cancer subject who has a mutation in an epidermal growth factor receptor (EGFR) family member, and administering to the subject an EGFR family member antagonist and a bisphosphonate that can bind to the EGFR family member. |
| 地址 |
New York NY US |
