发明名称 |
Stable and Soluble Formulations of Receptor Tyrosine Kinase Inhibitors, and Methods of Preparation Thereof |
摘要 |
The present disclosure relates to stable formulations of receptor tyrosine kinase inhibitors (TKI), e.g., pazopanib; methods of preparation thereof; and use of the disclosed formulations in sustained delivery of the active agent to a target site. The disclosure further relates to methods of converting one polymorphic Form of a TKI to another polymorphic Form and/or an amorphous form. |
申请公布号 |
US2016038488(A1) |
申请公布日期 |
2016.02.11 |
申请号 |
US201514819682 |
申请日期 |
2015.08.06 |
申请人 |
ForSight Vision4, Inc. |
发明人 |
Horvath Judit;Astafieva Irina;Erickson Signe;Farinas Kathleen Cogan |
分类号 |
A61K31/506;A61M5/14;A61K9/08;A61K47/32;A61K47/48;A61K9/00 |
主分类号 |
A61K31/506 |
代理机构 |
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代理人 |
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主权项 |
1. A stable pharmaceutical formulation comprising a pharmaceutically acceptable salt of a therapeutic agent having low aqueous solubility, and one or more formulation agents, wherein the pharmaceutically acceptable salt is a monovalent or a divalent salt, and the one or more formulation agents comprises a complexing agent, a solubilizing agent, and/or a buffering agent; wherein the salt of the therapeutic agent is in solution in the formulation. |
地址 |
Menlo Park CA US |