NEW CRYSTAL FORM OF ANTICANCER COMPOUND, PREPARATION METHOD AND USE THEREOF

摘要

Disclosed are a crystal form of an anticancer compound (R)-3-[1-(2, 6-dichloro-3-fluorophenyl) ethoxy]-5-[3-fluorophenyl-1-dimethyl phosphine acyl-oxy-4-yl] pyridine-2-amine and preparation method thereof. The structural formula of the crystal form is as represented by formula I. The crystal form has a stable property, a high purity, no hygroscopicity and high bioavailability, and meets requirements for pharmaceutical preparation.