| 主权项 |
1. A compound of formula I wherein R1 is selected from the group consisting of C3-10-cycloalkyl and heterocyclyl, both optionally substituted with 1 to 3 groups independently selected from HO—, NC—, HO2C—, HO2C—H2C—, C1-4-alkyl, C1-4-alkyl-O—, and HO—C1-4-alkyl-,
wherein heterocyclyl denotes a saturated mono-, bi- or spirocyclic ring system having 5 to 10 ring member atoms of which 1 or 2 not vicinal ring members are O atoms; R2 is selected from the group R2-G1 consisting of F, Cl, Br, NC—, C1-4-alkyl, and C1-4-alkyl-O—,
wherein any alkyl group and subgroup is optionally substituted with 1 or more F atoms; X is selected from the group X-G1 consisting of a bond, an arylene, and a heteroarylene group,
wherein said arylene and heteroarylene groups are optionally substituted with 1 to 3 groups independently selected from F, Cl, Br, I, NC—, HO—, HO2C—, C1-4-alkyl, C1-4-alkyl-O—, F3C—, and F3CO—; Y is selected from the group Y-G1 consisting of an arylene and a heteroarylene group,
wherein said arylene and heteroarylene groups are optionally substituted with 1 to 3 groups independently selected from F, Cl, Br, I, NC—, HO—, HO2C—, C1-4-alkyl, C1-4-alkyl-O—, F3C—, and F3CO—; Z is selected from the group Z-G1 consisting of RS(RNRN′N)(O═)S═N—, RS(RNRN′N)(O═)S═N—C1-3-alkyl-, (RN″)N═S(═O)(NRNRN′)—, (RN″)N═S(═O)(NRNRN′)—C1-3-alkyl-, wherein n=1 or 2,
RN and RN′ are independently selected from H, C1-4-alkyl, C3-7-cycloalkyl, C3-7-cycloalkyl-C1-3-alkyl-, heterocyclyl, heterocyclyl-C1-3-alkyl-, aryl-, aryl-C1-3-alkyl-, heteroaryl, heteroaryl-C1-3-alkyl-, orRN and RN′ together with the N-atom these groups are attached to form a 4-7 membered saturated monocyclic ring system,
wherein one —CH2-ring member optionally is replaced by —NRN′″— or −O—, wherein RN′″ is selected from H, H3C—, H5C2—, and cyclopropyl and wherein the ring system optionally is substituted with 1 to 3 groups independently selected from F, HO—, C1-3-alkyl, C1-3-alkyl-O—, (C1-3-alkyl)2-N—, HO2C—, C1-3-alkyl-C(═O)—, and C1-3-alkyl-S(═O)2—,RN″ is selected from H, NC—, C1-4-alkyl, C1-4-alkyl-C(═O)—, C1-4-alkyl-O—C(═O)—, C1-4-alkyl-N—C(═O)—, C3-7-cycloalkyl, C3-7-cycloalkyl-C1-3-alkyl-, C3-7-heterocyclyl, heterocyclyl-C1-3-alkyl-, aryl, aryl-C1-3-alkyl-, aryl-C(═O)—, aryl-O—C(═O)—, aryl-C1-3-alkyl-O—C(═O)—, aryl-S(═O)2, heteroaryl, and heteroaryl-C1-3-alkyl-, andRS is selected from C1-4-alkyl, C3-7-cycloalkyl, C3-7-cycloalkyl-C1-3-alkyl-, heterocyclyl, heterocyclyl-C1-3-alkyl-, aryl, aryl-C1-3-alkyl-, heteroaryl, heteroaryl-C1-3-alkyl-, and
wherein any alkyl, cycloalkyl, and heterocyclyl group mentioned within the definition of RN, RN′, RN″ and RS is optionally substituted with 1 to 3 groups independently selected from F, HO—, C1-3-alkyl-O—, (C1-3-alkyl)2-N—, HO2C—, C1-3-alkyl-C(═O)—, and C1-3-alkyl-S(═O)2—, andwherein any aryl and heteroaryl group mentioned within the definition of and RS is optionally substituted with 1 to 3 groups independently selected from F, Cl, Br, I, HO—, NC—, HO2C—, C1-3-alkyl, C1-3-alkyl-O—, C1-3-alkyl-S(═O)2—, F3C—, and F3CO—, wherein any heterocyclyl group mentioned hereinbefore, if not specified otherwise, denotes a saturated or partially unsaturated monocyclic or bicyclic fused, bridged or spiro group having 5 to 12 ring member atoms of which 4 to 11 ring members are C atoms and 1 to 3 ring members are heteroatoms selected from O, N, NRN″, and S(═O)r with r=0, 1 or 2, with the proviso that no O—O, S—S or S—O bond is formed,
wherein 1 CH2 ring member attached to a ring member N atom is optionally replaced by a —C(═O)— group,and wherein RN″ is defined as mentioned hereinbefore; wherein any arylene group mentioned hereinbefore denotes a bivalent aryl group; wherein any heteroarylene group mentioned hereinbefore denotes a bivalent heteroaryl group; wherein any aryl group mentioned hereinbefore, if not specified otherwise, denotes a carbocyclic aromatic monocyclic group containing 6 carbon atoms which may be further fused to a second 5- or 6-membered carbocyclic group which may be aromatic, saturated or unsaturated; wherein any heteroaryl group mentioned hereinbefore, if not specified otherwise, denotes
tetrazolyl,a 5-membered heteroaromatic ring containing
1 ring member selected from NRN′″, O and S, or1 N and 1 ring member selected from NRN′″, O and S, or1 NRN′″, O or S and 2 N,
wherein RN′″ is defined as mentioned hereinbefore, ora 6-membered heteroaromatic ring containing 1 to 3 N atoms; and wherein in any definition mentioned hereinbefore and if not specified otherwise, any alkyl group or sub-group may be straight-chained or branched, or a salt thereof. |
