发明名称 |
NEUROINVASION INHIBITOR |
摘要 |
The present inventors discovered that neural invasion is suppressed by inhibiting IL-6 in a model for neural invasion of pancreatic cancer, and completed the present invention. The present inventors also demonstrated that: an IL-6 receptor is expressed in cells of human pancreatic cancer cell lines; and IL-6 enhances the chemotactic and migratory activities and intracellular signaling of pancreatic cancer cells; and thus pancreatic cancer can be treated by inhibiting IL-6. Furthermore, the present inventors found that neural invasion of human pancreatic cancer can be suppressed, from the results of administering IL-6 inhibitors to neural invasion model mice. |
申请公布号 |
EP2305306(B1) |
申请公布日期 |
2016.02.10 |
申请号 |
EP20090758415 |
申请日期 |
2009.06.05 |
申请人 |
NATIONAL CANCER CENTER;CHUGAI SEIYAKU KABUSHIKI KAISHA |
发明人 |
MITSUNAGA, SHUICHI;OCHIAI, ATSUSHI |
分类号 |
A61K45/00;A61K39/395;A61P1/18;A61P25/00;A61P35/00;A61P43/00;C07K16/28 |
主分类号 |
A61K45/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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