发明名称 |
POLYPEPTIDE HAVING SIALYLATED SUGAR CHAINS ATTACHED THERETO |
摘要 |
The object of the present invention is to provide a polypeptide having interferon ² activity glycosylated with highly uniform sialylated sugar chains. The present invention is a glycosylated polypeptide, wherein the polypeptide is any polypeptide selected from the group consisting of the following (1) to (4);
(1) a polypeptide consisting of the amino acid sequence represented by SEQ ID NO. 1,
(2) a polypeptide having one or a few amino acids deleted, substituted, or added in the polypeptide consisting of the amino acid sequence represented by SEQ ID NO. 1,
(3) a polypeptide that is an analog of interferon ², and
(4) a polypeptide having 80% or more homology to the polypeptide consisting of the amino acid sequence represented by SEQ ID NO. 1,
in which amino acids at 4 to 6 locations are substituted with glycosylated amino acids, and
wherein all of the non-reducing terminals of said sugar chain are sialylated. |
申请公布号 |
EP2982686(A1) |
申请公布日期 |
2016.02.10 |
申请号 |
EP20140776069 |
申请日期 |
2014.03.24 |
申请人 |
GLYTECH, INC. |
发明人 |
OHUCHI, MASAKI;NISHIHARA, MIKA;TEZUKA, KATSUNARI;MAEDA, MASATOSHI;KAJIHARA, YASUHIRO;SAKAMOTO, IZUMI |
分类号 |
C07K14/565;A61K38/00;A61P1/16;A61P25/00;A61P31/14;A61P35/00 |
主分类号 |
C07K14/565 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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