发明名称 大環式プロリン由来HCVセリンプロテアーゼ阻害剤
摘要 The present invention discloses compounds of Formula I or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
申请公布号 JP5857053(B2) 申请公布日期 2016.02.10
申请号 JP20130529408 申请日期 2011.09.20
申请人 エナンタ ファーマシューティカルズ インコーポレイテッド 发明人 オア,ヤツト・スン;マー,ジユイン;ワン,グオチアン;ロン,ジアン;ワン,ビン
分类号 C07K5/08;A61K31/13;A61K31/7056;A61K38/00;A61K38/21;A61K45/00;A61P31/12;A61P31/14;A61P43/00;C07K5/12 主分类号 C07K5/08
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