发明名称 |
vacina de rotavírus estável, secada, composições e processo para preparação da mesma |
摘要 |
The present invention provides novel lyophilized rotavirus vaccine formulations and methods of their preparation. The formulations include vaccine stabilizers, resulting in a vaccine formulation with enhanced stability and minimal loss of potency. The rotavirus vaccine formulations comprise an advantageous ratio of a disaccharide (such as sucrose) to an amino acid (such as glycine). The lyophilization results in a virus formulation with 100% virus preservation and residual moisture from about 0.8% to 1.4%. |
申请公布号 |
BRPI0915696(A2) |
申请公布日期 |
2016.02.10 |
申请号 |
BR2009PI15696 |
申请日期 |
2009.11.06 |
申请人 |
SERUM INSTITUTE OF INDIA LIMITED |
发明人 |
JAGDISH K. ZADE;RAJEEV M. DHERE;SAMBHAJI S. PISAL |
分类号 |
A61K39/15 |
主分类号 |
A61K39/15 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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