发明名称 |
ErbB/ErbBリガンドに関連する疾患を治療するための分子及びその分子を使用する方法 |
摘要 |
A method of selecting a target for treatment of a hyperproliferative disease in a subject in need thereof is disclosed. The method comprising analyzing an amount and/or activity of at least one ErbB ligand in a biological sample from the subject, wherein an ErbB ligand which shows an up-regulated amount and/or activity compared to a non-hyperproliferative cell or tissue above a predetermined level is selected as a target for treatment of the hyperproliferative disease. Methods of treating hyperproliferative diseases, monoclonal antibodies and pharmaceutical compositions are also disclosed. |
申请公布号 |
JP5858984(B2) |
申请公布日期 |
2016.02.10 |
申请号 |
JP20130505597 |
申请日期 |
2011.03.22 |
申请人 |
イェダ リサーチ アンド デベロップメント カンパニー リミテッド |
发明人 |
リンゼン, モシト;ヤーデン, ヨセフ |
分类号 |
G01N33/574;A61K31/713;A61K39/395;A61K45/00;A61K48/00;A61P35/00;A61P35/02;A61P43/00;C07K16/22;G01N33/543 |
主分类号 |
G01N33/574 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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