发明名称 |
小胞を調製する方法及びこれから製造される製剤 |
摘要 |
The present disclosure provides methods for preparing vesicles. In some embodiments, the methods involve providing a molten mixture of vesicle forming lipids and then adding the molten mixture to an aqueous solution comprising an antigen such that antigen-containing vesicles are formed. In other embodiments, the methods involve providing a lyophilized lipid product and rehydrating the lyophilized lipid product with an aqueous solution comprising an antigen such that antigen-containing vesicles are formed. The lyophilized lipid product is prepared by melting vesicle-forming lipids to produce a molten lipid mixture and then lyophilizing the molten lipid mixture. The present disclosure also provides antigen-containing vesicle formulations prepared using these methods. The present disclosure also provides kits that include a lyophilized lipid product in a first container and an aqueous solution comprising an antigen in a second container. |
申请公布号 |
JP5854559(B2) |
申请公布日期 |
2016.02.09 |
申请号 |
JP20120519672 |
申请日期 |
2010.07.06 |
申请人 |
ヴァリエーション バイオテクノロジーズ インコーポレイテッド |
发明人 |
アンダーソン, デイヴィッド, イー.;オグレル, アンドレイ |
分类号 |
A61K39/00;A61K9/127;A61K39/12;A61K39/145;A61K39/21;A61K39/29;A61K39/295;A61K39/39;A61K47/10;A61K47/12;A61K47/14;A61K47/16;A61K47/20;A61K47/24;A61K47/26;A61K47/28;A61K47/34;A61K47/36;A61K47/42 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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