Method and device for detecting an analyte in a body fluid

摘要

A method for detecting at least one analyte in at least one sample of a body fluid is disclosed. Therein, at least one test element (124) is used, the at least one test element (124) having at least one test field (162) with at least one test chemistry (154) is used, wherein the test chemistry (154) is adapted to perform at least one optically detectable detection reaction in the presence of the analyte. The method comprises acquiring an image sequence of images of the test field (162) by using at least one image detector (178). Each image comprises a plurality of pixels. The method further comprises detecting at least one characteristic feature of the test field (162) in the images of the image sequence. The method further comprises correcting a relative position change between the image detector (178) and the test field (162) in the image sequence by using the characteristic feature, thereby obtaining a sequence of corrected images.

主权项

1. A method for detecting at least one analyte in at least one sample of a body fluid, wherein at least one test element with at least one test field is used, the at least one test field having at least one test chemistry, wherein the test chemistry is adapted to perform at least one optically detectable detection reaction in the presence of the analyte, wherein the method comprises acquiring an image sequence of images of the test field by using at least one image detector, wherein each image comprises a plurality of pixels, wherein the method further comprises detecting at least one characteristic feature of the test field in the images of the image sequence, wherein the method further comprises correcting a relative position change between the image detector and the test field in the image sequence by using the characteristic feature, thereby obtaining a sequence of corrected images, wherein the sequence of corrected images is adapted for observing a time-dependent change of at least one optically detectable property of the test field due to the detection reaction of the test chemistry with the analyte to be detected;
wherein the correction of the relative position change comprises using at least one image of the image sequence as a reference image, wherein the reference image is kept unchanged, wherein the remaining images of the image sequence are corrected by using at least one calculational correction of the position of the pixels, wherein the calculational correction is chosen such that a correlation between the reference image and the corrected remaining images of the image sequence is maximized; and wherein the calculational correction comprises at least one of the following:
a shifting of the pixels of the remaining images of the image sequence in at least one spatial direction, wherein the shifting is chosen such that the correlation between the reference image and the corrected remaining images is maximized; orat least one rotation of the remaining images of the image sequence about at least one rotational axis by at least one rotation angle, wherein one or both of the rotational axis and the rotation angle are chosen such that the correlation between the reference image and the corrected remaining images is maximized.