Methods of developing a prognosis for pancreatic cancer and predicting responsiveness to cancer therapeutics

摘要

Methods of predicting responsiveness of a cancer in a subject to a cancer therapy including a VEGF targeting agent are provided herein. The methods include detecting the expression level of at least one biomarker selected from ANG-2, SDF-1 and VEGF-D in a sample from the subject and using the expression levels to determine whether the VEGF targeting agent will be effective to treat the cancer in the subject. The predictions may be used to develop treatment plans for the subjects. Methods of developing a prognosis for a subject with pancreatic cancer are also provided. These methods include determining the expression level of IGFBP-1, PDGF-AA and at least one of IL-6 or CRP in a sample from a subject with pancreatic cancer.

主权项

1. A method of predicting responsiveness of pancreatic cancer in a subject to a cancer therapy including a VEGF targeting agent comprising: obtaining a sample from the subject; measuring an protein expression level of at least one biomarker selected from Ang-2, SDF-1 and VEGF-D in the sample from the subject; and treating the subject with a VEGF targeting agent if the expression level of Ang-2 is greater than 305 pg/mL, the expression level of SDF-1 is more than 1100 pg/mL, or the expression level of VEGF-D is less than 1100 pg/mL.