The present invention relates to new methods for diagnosing a pregnancy-associated disorder by analyzing fetal DNA present in the mother's blood. More specifically, this invention relies on the discovery that the maspin gene is differentially methylated in fetal DNA and in maternal DNA and provides these new diagnostic methods, which distinguish fetal DNA from maternal DNA and detect prenatal disorders based on abnormalities in fetal DNA level and methylation status.
申请公布号
CA2568755(C)
申请公布日期
2016.02.09
申请号
CA20052568755
申请日期
2005.06.06
申请人
THE CHINESE UNIVERSITY OF HONG KONG
发明人
LO, YUK MING DENNIS;CHIU, ROSSA WAI KWUN;CHIM, STEPHEN SIU CHUNG;TONG, YU-KWAN;DING, CHUNMING