| 摘要 |
Method and apparatus for synthesizing an F-18 labeled radioactive pharmaceutical by labeling a precursor with an F-18 radioactive isotope, by reacting the labeled precursor to obtain a labeled pharmaceutical, by separating impurities from the labeled pharmaceutical to provide a purified labeled pharmaceutical, and by collecting the purified labeled pharmaceutical. The apparatus includes a labeling cartridge that contains the precursor, receives the isotope, and causes a labeling reaction to provide the labeled precursor; a synthesizing container that receives the labeled precursor, receives at least one reagent effective to hydrolyze the labeled precursor, and within which the labeled precursor undergoes a hydrolysis reaction to provide the labeled pharmaceutical; and a separation cartridge that receives the labeled pharmaceutical, and contains a polymer compound that separates impurities into polar compounds and nonpolar compounds to provide the purified labeled pharmaceutical. The labeling and separation cartridges may be contained in a removable cassette. |
| 主权项 |
1. An apparatus for synthesizing an F-18 labeled radioactive pharmaceutical by labeling a precursor of a pharmaceutical with an F-18 radioactive isotope to provide an F-18 labeled precursor, by reacting the F-18 labeled precursor to obtain a crude F-18 labeled pharmaceutical, by separating impurities from the crude F-18 labeled pharmaceutical to provide a purified F-18 labeled pharmaceutical, and by collecting the purified F-18 labeled pharmaceutical, the apparatus comprising:
an F-18 radioactive isotope supplier which supplies an F-18 radioactive isotope; a reagent supplier which supplies at least one reagent; a labeling cartridge that contains the precursor, that receives the F-18 radioactive isotope, and that causes a labeling reaction to provide the F-18 labeled precursor; a first heating unit that selectively heats the labeling cartridge; a synthesizing container that receives the F-18 precursor, that receives at least one reagent effective to hydrolyze the F-18 labeled precursor, and within which the F-18 labeled precursor undergoes a hydrolysis reaction to provide the F-18 labeled pharmaceutical; a second heating unit which selectively heats the synthesizing container; a separation cartridge that receives the F-18 labeled pharmaceutical, and that contains a polymer compound that separates impurities into polar compounds and nonpolar compounds to provide a purified F-18 labeled pharmaceutical; a waste liquid container which receives and contains fluid which is discarded after synthesis; a collecting container which collects the F-18 labeled pharmaceutical from the separation cartridge; a transmitting gas supplier which supplies a flow of transmitting gas; a cleansing liquid supplier which supplies a cleansing liquid; a connection tube which connects the F-18 radioactive isotope supplier, the reagent supplier, the labeling cartridge, the separation cartridge, the synthesizing container, the waste liquid container, the collection container, the transmitting gas supplier, and the cleansing liquid supplier together; a plurality of control valves which are disposed at predetermined positions of the connection tube to perform selective opening and closing operations; and a controller which controls operations of the first heating unit, the second heating unit, and the plurality of the control valves. |
