Stable aqueous formulations of adenovirus vectors

摘要

The present invention is based on the surprising discovery that the inclusion of an anionic polymer in the adenovirus formulation enhances long-term stability of the vector composition. An aqueous formulation comprising an adenovirus vector and at least one anionic polymer is provided, together with methods of the preparation of a storage stable adenovirus aqueous formulation.

主权项

1. An aqueous formulation comprising an adenovirus vector and a dextran sulfate or salt form thereof at a concentration ranging from about 0.5 mg/mL to about 10 mg/mL.