Modulators of ATP-binding cassette transporters

摘要

Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.

主权项

1. A compound of formula II: or a pharmaceutically acceptable salt thereof, wherein independently for each occurrence: R is H, OH, OCH3 or two R taken together form —OCH2O— or —OCF2O—; R1 is H or up to two C1-C6 alkyl; R2 is H or halo; R3 is H or C1-C6 alkyl; and Y is O.