Compounds having antibacterial activity, process for their preparation and pharmaceutical compositions comprising them

摘要

A pharmaceutically acceptable salt, prodrug or derivative compound of the formula I, wherein R1 is selected from H, a (C1-C5) alkyl group and a COR4 group; R2 is selected from H, a (C1-C5) alkyl group and a COR5 group; R3 is selected from H, a (C1-C5) alkyl group, a (C1-C5)-O-alkyl group, a cycloalkyl of (C5-C6) carbon atoms, an aryl group, and an aryl (C1-C5) alkyl group wherein the aryl group can be an unsubstituted aryl or substituted with one or more R6 groups and an NHCOR5 group, or the R2 and R3 groups together with N may form a piperidine, morpholine or piperazine group; R4 is selected from H and a (C1-C5)alkyl group; R5 is selected from an aryl group unsubstituted or substituted with one or more R6, linear or branched(C1-C5) alkyl or pyridyne groups and a pyridine group; R6 is selected from (C1-C5)alkyl groups, halogen and nitro.

主权项

1. A compound of the following structural formula: a pharmaceutically acceptable salt or prodrug, wherein R1 is selected from the group consisting of H, a linear or branched (C1-C5) alkyl group and a COR4 group; R2 is selected from the group consisting of H, a linear or branched (C1-C5) alkyl group and a COR5 group; R3 is selected from the group consisting of H, a linear or branched (C1-C5)alkyl group, a linear or branched (C1-C5)-O-alkyl group, a cycloalkyl of (C5-C6) carbon atoms, an aryl group, and an aryl (C1-C5) alkyl group wherein the aryl group can be an unsubstituted aryl or an aryl substituted with one or more R6 groups and an NHCOR5 group, or the R2 and R3 groups together with N may form a substituted or unsubstituted piperidine, morpholine or piperazine group; R4 is selected from the group consisting of H and a (C1-C5)alkyl group; R5 is an unsubstituted aryl group or an aryl group substituted with one or more R6, linear or branched(C1-C5) alkyl or a pyridine group; and R6 is selected from the group consisting of (C1-C5)alkyl groups, halogen and nitro, provided that R1, R2 and R3 are not H atoms at the same time.