发明名称 |
Antibody specifically recognizing an epitope for switching to T<sub>H</sub>1 cell |
摘要 |
The present invention relates to a novel epitope that converts T cell to type 1 helper T (TH1) cell. Specifically, the present invention relates to an epitope constituting the 56th to 65th amino acids (SEQ ID No. 2) of extracellular domain (ECD) of activation-inducible tumor necrosis factor receptor (AITR), an antibody recognizing the epitope, a polynucleotide encoding the epitope, a polynucleotide encoding the antibody, an expression vector comprising the polynucleotide encoding the epitope or antibody, a transformant introduced with the vector, a composition comprising the antibody for converting T cell to TH1 cell and a method for converting T cell to TH1 cell, a pharmaceutical composition comprising the antibody for preventing or treating cancer, a method for treating cancer using the antibody, a composition comprising the antibody for enhancing immunity, and a method for enhancing immunity using the antibody. |
申请公布号 |
US9255151(B2) |
申请公布日期 |
2016.02.09 |
申请号 |
US201313861644 |
申请日期 |
2013.04.12 |
申请人 |
National Cancer Center |
发明人 |
Kwon Byoung Se |
分类号 |
A61K39/395;C07K16/28;C07K16/30;C07K7/06;C07K14/705;A61K39/00 |
主分类号 |
A61K39/395 |
代理机构 |
Reinhart Boerner Van Deuren P.C. |
代理人 |
Reinhart Boerner Van Deuren P.C. |
主权项 |
1. An antibody specifically recognizing on epitope of activation-inducible tumor necrosis factor receptor (AITR), wherein the epitope is represented by SEQ ID No. 2 and wherein the antibody comprises a heavy chain variable region comprising heavy chain complementarity-determining region (CDR) 1 represented by SEQ ID No. 6; heavy chain CDR2 represented by SEQ ID No. 7; and heavy chain CDR3 represented by SEQ ID No. 8, and a light chain variable region comprising light chain CDR1 represented by SEQ ID No. 10; light chain CDR2 represented by SEQ ID No. 11; and light chain CDR3 represented by SEQ ID No. 12. |
地址 |
Goyang-Si, Gyeonggi-Do KR |