Angiopoietin derived peptides

摘要

Provided are angiopoietin-derived peptides or homologs or derivatives thereof, pharmaceutical composition including them, a use thereof for therapy and for the manufacture of a medicament, a method of treating a wide range of conditions, disorders and diseases therewith, nucleotide sequences encoding them, antibodies directed to epitopes thereof and fusion proteins including them.

主权项

1. An isolated peptide consisting of an amino acid sequence selected from the group consisting of:
an amino acid sequence as set forth in any one of SEQ ID NOs: 7-9, or a homolog or a derivative thereof, wherein said peptide has antiangiogenic activity, and wherein said peptide having an amino acid sequence as set forth in SEQ ID NO: 7, or the homolog or derivative thereof has at most 56 amino acids, wherein said peptide having an amino acid sequence as set forth in SEQ ID NO: 8, or the homolog or derivative thereof has at most 43 amino acids and wherein said peptide having an amino acid sequence as set forth in SEQ ID NO: 9, or the homolog or derivative thereof has at most 38 amino acids and wherein said homolog or derivative differs from said amino acid sequence by conservative amino acid substitutions.