| 主权项 |
1. A method of inhibiting expression of MCP-1, CX3CR1, or p40, the method comprising;
administering to a person in need thereof, an effective amount of a compound of formula (I):wherein
A is a σ bond, —X1— or —X1—O—X2—, in which
X1 and X2, which may be identical or different from each other, are an alkyl group having from 1 to 5 carbon atoms, optionally substituted with one or more alkyl groups having from 1 to 5 carbon; Y is H when A is a σ bond, or Y is H, —OH, or —N(R11)(R12) when A is X1— or —X1—O—X2—, in which
R11 is hydrogen, an alkyl group having from 1 to 5 carbon atoms, or R11 together withR12 forms a 5- to 6-membered heterocycle,R12 is hydrogen, an alkyl group having from 1 to 5 carbon atoms, or R12 together withR11 forms a 5- to 6-membered heterocycle; R1 and R2, which may be identical or different from each other, are hydrogen or an alkyl group having from 1 to 5 carbon atoms; R3, R4 and R8, which may be identical or different from each other, are hydrogen, an alkyl group having from 1 to 5 carbon atoms, an alkoxy group having from 1 to 3 carbon atoms, a halogen atom, —OH, —N(R′)(R″), —N(R′)COR″, —CN, —CONR′R″, nitro, or trifluoromethyl; with R′ and R″, which may be identical or different from each other, being hydrogen or an alkyl group having from 1 to 5 carbon atoms; R5 is hydrogen, an alkyl group having from 1 to 5 carbon atoms, or R5 together with one from between R6 and R7 forms a ring having 5 or 6 carbon atoms; R6 and R7, which may be identical or different from each other, are hydrogen or an alkyl group having from 1 to 5 carbon atoms, or together form a group C═O, or one from between R6 and R7, together with R5, forms a ring having 5 or 6 carbon atoms, thereby inhibiting the expression of MCP-1, CX3CR1, or p40, wherein a disease treatable by said inhibition is at least one disease selected from the group consisting of a metabolic syndrome, obesity, diabetes, insulin resistance, rheumatoid arthritis, arthritis induced by viral infections, psoriatic arthritis, arthrosis, lupus nephritis, diabetic nephropathy, glomerulonephritis, polycystic kidney disease, interstitial lung disease, fibrosis, multiple sclerosis, Alzheimer's disease, HIV-associated dementia, atopic dermatitis, psoriasis, vasculitis, restenosis, atherosclerosis, myocardial infarction, angina, acute coronary disease, a complication following surgical intervention, Crohn's disease, ulcerative colitis, a coronary disorder, and lupus erythematosus. |
