发明名称 |
Methods of therapeutic monitoring of nitrogen scavenging drugs |
摘要 |
The present disclosure provides methods for evaluating daily ammonia exposure based on a single fasting ammonia blood level measurement, as well as methods that utilize this technique to adjust the dosage of a nitrogen scavenging drug, determine whether to administer a nitrogen scavenging drug, and treat nitrogen retention disorders. |
申请公布号 |
US9254278(B2) |
申请公布日期 |
2016.02.09 |
申请号 |
US201514816674 |
申请日期 |
2015.08.03 |
申请人 |
Horizon Therapeutics, Inc. |
发明人 |
Scharschmidt Bruce;Mokhtarani Masoud |
分类号 |
A61K49/00;A61P13/00;A61K31/216;A61K9/00;G01N31/22;G01N33/49 |
主分类号 |
A61K49/00 |
代理机构 |
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代理人 |
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主权项 |
1. A method of treating a subject with a urea cycle disorder, the method comprising:
administering to the subject in need thereof glyceryl tri-[4-phenylbutyrate] in an amount sufficient to produce a fasting plasma ammonia level that is less than half the upper limit of normal for plasma ammonia level. |
地址 |
Deerfield IL US |