Porous SERS analytical devices and methods of detecting a target analyte

摘要

A surface enhanced Raman spectroscopy (SERS) analytical device includes a substrate having a porous structure, and a plurality of plasmonic nanoparticles embedding in the porous structure and forming a sensing region. A method of detecting a target analyte in a sample includes contacting the sample with the substrate, whereby the target analyte, if present in the sample, is concentrated in the sensing matrix. The substrate may then be analyzed using SERS detection equipment.

主权项

1. A surface enhanced Raman spectroscopy (SERS) analytical device, comprising:
a substrate having a porous structure, said substrate comprising a material selected from the group consisting of nylon, polyvinylidene fluoride (PVDF), cellulose, modified cellulose, a natural polymer, a synthetic polymer, glass fibers, and a combination thereof; and a plurality of plasmonic nanoparticles embedded onto discrete portions of said porous structure, wherein said plasmonic nanoparticles are randomly distributed and form plasmonic nanoparticle clusters, and wherein said plasmonic nanoparticles do not entirely cover a surface of said substrate, and a portion of said surface of said substrate is free from any metal coating.