| 摘要 |
The invention relates to fused bicycloheterocycle substituted azabicyclic alkane derivatives of formula (I), or a pharmaceutically acceptable salt, ester, amid, or prodrug thereof, wherein n is 1, 2 or 3; A is N or N+-O-; R is hydrogen, alkyl, cycloalkylalkyl and arylalkyl; L is selected from the group consisting of O, S, and -N(Ra)-; Ar1 is a 6-membered aryl or 6 membered heteroaryl ring; and Ar2 is a bicyclic heteroaryl; and Ra is selected from the group consisting of hydrogen, alkyl and alkylcarbonyl; provided that if Ar1 is Formula (II), then L is O or S. Compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions. |
