Live attenuated virus vaccines for La Crosse virus and other Bunyaviridae

摘要

The invention relates to vaccine compositions including CEV serogroup immunogens, attenuated and inactivated viruses of the CEV serogroup and chimeric Bunyaviridae. Also disclosed are methods of treating or preventing CEV serogroup infection in a mammalian host, methods of producing a subunit vaccine composition or an immunogenic composition, isolated polynucleotides comprising a nucleotide sequence encoding a CEV serogroup immunogen, methods for detecting La Crosse virus (LACV) infection in a biological sample and infectious chimeric Bunyaviridae.

主权项

1. An infectious chimeric virus comprising a La Crosse virus genome, wherein the GC or GN gene of the La Crosse virus genome is substituted with the counterpart GC or GN gene from a second member of the Bunyaviridae family, wherein the second member is a Jamestown Canyon virus.