| 主权项 |
1. A method for treating a disease in a mammalian subject, said method comprising administering to the subject a therapeutically effective amount of a formulation comprising a biologically active molecule, a compound of Formula A and a compound of Formula B: wherein n1, n2, and n3 in both Formula A and Formula B are independently 1, 2, 3, or 4; X and X′ in both Formula A and Formula B are independently a bond, oxygen, or nitrogen; R1 and R2 in both Formula A and Formula B are independently C8-C25 hydrocarbon groups optionally containing from 1-4 double or triple bonds; in Formula A, G is hydrogen; and in Formula B, G is a polyoxyalkylene, polyvinylpyrrolidone, polyacrylamide, polydimethylacrylamide, polyvinyl alcohol, dextran, poly (L-glutamic acid), styrene maleic anhydride, poly-N-(2-hydroxypropyl) methacrylamide, or polydivinylether maleic anhydride; and wherein the biologically active molecule is selected from the group consisting of: ribosomal RNA; antisense polynucleotides of RNA or DNA; ribozymes; siRNA; shRNA; miRNA; and polynucleotides of genomic DNA, cDNA, or mRNA that encode for a therapeutically useful protein. |
