发明名称 |
Methods and compositions for inhibiting or reducing hair loss, acne, rosacea, prostate cancer, and BPH |
摘要 |
This invention provides methods of treating androgenetic alopecia (AGA), acne, rosacea, prostate cancer, and benign prostatic hypertrophy (BPH), comprising the step of contacting a subject with a compound or composition capable of decreasing prostaglandin D2 (PGD2) level or activity, a downstream signaling or receptor pathway thereof, or prostaglandin D2 synthase level or activity; methods of stimulating hair growth, comprising the step of contacting a subject with a compound or composition capable of increasing or decreasing the activity or level of a target gene of the present invention, or with a protein product of the target gene or an analog or mimetic thereof; and methods of testing for AGA and evaluating therapeutic methods thereof, comprising measuring PGD2 levels. |
申请公布号 |
US9254293(B2) |
申请公布日期 |
2016.02.09 |
申请号 |
US200712303998 |
申请日期 |
2007.06.15 |
申请人 |
The Trustees of the University of Pennsylvania |
发明人 |
Cotsarelis George;Garza Luis |
分类号 |
A61K48/00;A61K31/557;A61K8/36;A61K31/7088;A61K31/713;A61Q7/00 |
主分类号 |
A61K48/00 |
代理机构 |
Pearl Cohen Zedek Latzer Baratz LLP |
代理人 |
Cohen Mark S.;Pearl Cohen Zedek Latzer Baratz LLP |
主权项 |
1. A method of treating acne or rosacea in a subject, the method comprising the step of contacting said subject with a prostaglandin D2 antagonist, thereby treating acne or rosacea, respectively, in the subject. |
地址 |
Philadelphia PA US |