发明名称 |
CHIMERIC CLOTTING FACTORS |
摘要 |
The invention provides chimeric clotting factors comprising an activatable clotting factor and an enhancer moiety. The activatable clotting factor allows the chimeric clotting factor to be activated at the site of coagulation. The enhancer moiety can additionally improve procoagulation activities of the chimeric clotting factors. The chimeric clotting factors can further be improved by fusion to a half-life extender, which improves a pharmacokinetics property of the chimeric clotting factor. The invention also includes methods of making and methods of using these chimeric clotting factors. |
申请公布号 |
HK1207591(A1) |
申请公布日期 |
2016.02.05 |
申请号 |
HK20150108385 |
申请日期 |
2015.08.28 |
申请人 |
BIOGEN MA INC. |
发明人 |
SALAS, JOE;KISTANOVA, ELENA;HONG, VU PHONG;MEZO, ADAM R. R;PETERS, ROBERT |
分类号 |
A61K;A61P |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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