SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF

摘要

This invention provides compounds of formula (I):;wherein R1, R2, G, m, n, p and q have values as described in the specification, useful as inhibitors of HDAC6. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of proliferative, inflammatory, infectious, neurological or cardiovascular diseases or disorders.

主权项

1. A compound of formula (I): or a pharmaceutically acceptable salt thereof; wherein: p is 0 and q is 3; or p is 1 and q is 2; or p is 2and q is 1; G is —R3, —V1—R3, —V1-L1-R3, -L1-V2—R3, -L1-R3, or -L1-V2-L2-R3; L1 and L2 are each independently unsubstituted or substituted C1-3 alkylene chain, where one carbon atom may be replaced with CRA═CRA—; V1 is —C(O)—, —C(S)—, —C(O)—N(R4a)—, —C(O)—O—, or —S(O)2—; V2 is —C(O)—, —C(S)—, —N(R4a)—, —C(O)—N(R4a)—, —N(R4a)—C(O)—, —SO2—N(R4a)—, —N(R4a)—SO2≦, —C(O)—O—, —O—C(O)—, —O—, —S—, —S(O)—, —S(O)2—, —N(R4a)—C(O)—N(R4a)—, —N(R4a)—C(O)—O—, —O—C(O)—N(R4a)—, or —N(R4a)—SO2—N(R4a)—; R3 is unsubstituted or substituted C1-6 aliphatic, unsubstituted or substituted 3-10-membered cycloaliphatic, unsubstituted or substituted 4-10-membered heterocyclyl having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur, unsubstituted or substituted 6-10-membered aryl, or unsubstituted or substituted 5-10-membered heteroaryl having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur; each occurrence of RA is independently hydrogen, halo, or an optionally substituted C1-4 aliphatic group; each occurrence of R4a is independently hydrogen, or an optionally substituted C1-4 aliphatic group; ring B is optionally further substituted with m occurrences of R1; each occurrence of R1 is independently halo, C1-3 alkyl, C1-3haloalkyl, —O—C1-3 alkyl, —O—C1-3 haloalkyl, —CN, —NHC(O)C1-3 alkyl, —NHC(O)NHC1-3 alkyl, or NHS(O)2C1-3 alkyl; ring A is optionally further substituted with n occurrences of R2; each occurrence of R2 is independently halo, C1-3 alkyl, C1-3haloalkyl, —O—C1-3 alkyl, —O—C1-3 haloalkyl, —NHC(O)C1-3 alkyl, —NHC(O)NHC1-3 alkyl, or NHS(O)2C1-3 alkyl; m is 0-2; and n is 0-4.