| 发明名称 |
METHODS FOR THE TREATMENT OF AUTOIMMUNE DISEASES |
| 摘要 |
The present invention provides a method for inducing CD8+FOXP3+ regulatory T cells in a subject which comprises administering to the subject: (i) a first agent which inhibits p38 phosphorylation; and (ii) a second agent which stimulates T-cell receptor (TCR) signalling. The method may be used to treat and/or prevent an autoimmune and/or inflammatory disease in a subject. The invention also provides compositions and kits for use in such methods. |
| 申请公布号 |
US2016030439(A1) |
申请公布日期 |
2016.02.04 |
| 申请号 |
US201414780104 |
申请日期 |
2014.03.28 |
| 申请人 |
UCL BUSINESS PLC |
发明人 |
Ellis Shawn;Notley Clare;Ehrenstein Michael |
| 分类号 |
A61K31/5377;G01N33/564;C07K16/28;G01N33/68;A61K39/395;A61K45/06 |
主分类号 |
A61K31/5377 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for inducing CD8+FOXP3+ regulatory T cells in a subject which comprises administering to the subject:
(i) a first agent which inhibits p38 phosphorylation; and (ii) a second agent which stimulates T-cell receptor (TCR) signalling. |
| 地址 |
London GB |
