| 摘要 |
(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date W O 2013/128276 A2 6 September 2013 (06.09.2013) W I PO I P CT (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every A61K 9/16 (2006.01) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (21) International Application Number: BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, PCT/IB2013/000444 DO, DZ, EC, EE, EG, ES, Fl, GB, GD, GE, GH, GM, GT, (22) International Filing Date: HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, 1 March 2013 (01.03.2013) KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, (25) Filing Language: English NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, (26) Publication Language: English RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, (30) Priority Data: ZM, ZW. 61/606,156 2 March 2012 (02.03.2012) US 61/724,141 8 November 2012 (08.11.2012) US (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (71) Applicant (for all designated States except US): RHODES GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, PHARMACEUTICALS L.P. [US/US]; 498 Washington UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, Street, Coventry, Rhode Island 02816 (US). TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (72) Inventors; and EE, ES, Fl, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, (71) Applicants (for US only): ADJEI, Akwete, L. [US/US]; MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, 125 Bailey Boulevard, East Greenwich, RI 02818 (US). TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, CHEN, Sibao [CN/US]; 940 Quaker Lane, #2901, War- ML, MR, NE, SN, TD, TG). wick, RI 02818 (US). KUPPER, Robert, Joe [US/US]; Published: 755 Major Potter Road, Warwick, RI 02818 (US). MAN- _ without international search report and to be republished CINELLI, Vincent [US/US]; 80 Oakwood Drive, Scitu- upon receipt of that report (Rule 48.2(g)) ate, RI 02825 (US). (54) Title: TAMPER RESISTANT IMMEDIATE RELEASE FORMULATIONS (57) Abstract: Disclosed in certain embodiments is an immediate release solid oral dosage form comprising a plurality of particles, f4 each particle comprising: (i) a core comprising a first active agent; (ii) a coating comprising a second active agent layered over the core; and (iii) a material that is sensitive to acidic pH layered over the coated core; wherein the dosage form releases at least about 70% of the second active agent within 45 minutes as measured by in-vitro dissolution in a USP Apparatus 2 (paddle) at 50 rpm in 500 ml 0.1 N HCl at 37* C. |
