| 主权项 |
1. A compound having the formula: or a pharmaceutically acceptable salt thereof, whereinR1 is a member selected from the group consisting of C1-C8 alkyl, C3-C8 cycloalkyl, C3-C8 cycloalkyl-C1-C3 alkyl, 4- to 7-membered heterocycloalkyl, 4- to 7-membered heterocycloalkyl-C1-C3 alkyl, phenyl, phenyl-C1-C3 alkyl, 5- to 6-membered heteroaryl and 5- to 6-membered heteroaryl-C1-C3 alkyl, wherein each R1 is optionally substituted with from 1-3 Ra;R2 is a member selected from the group consisting of C3-C8 cycloalkyl, C3-C8 cycloalkyl-C1-C3 alkyl, 4- to 7-membered heterocycloalkyl, and 4- to 7-membered heterocycloalkyl-C1-C3 alkyl, wherein each R2 is optionally substituted with from 1-5 Rb;R3 is a member selected from the group consisting of H, C1-C4 alkyl, C3-C4 cycloalkyl, and 4- to 7-membered heterocycloalkyl wherein each R3 is optionally substituted with from 1-2 Rc;R4 is a member selected from the group consisting of H and C1-C4 alkyl;or optionally, R3 and R4 are combined with the carbon atom to which each is attached, to form a 3- or 4-membered cycloalkyl or heterocycloalkyl ring;X is a member selected from the group consisting of H and F;each Ra is independently selected from the group consisting of halo, CN, hydroxyl, C1-C4 alkyl, C1-C4 haloalkyl, C1-C4 alkoxy, —CORa1, —CO2Ra1, —SO2Ra1, —SO2NRa1Ra2, and —CONRa1Ra2, wherein each Ra1 and Ra2 is independently selected from the group consisting of H and C1-C4 alkyl or optionally Ra1 and Ra2 when attached to a nitrogen atom are combined to form a 4- to 6-membered ring;each Rb is independently selected from the group consisting of halo, CN, hydroxyl, C1-C4 alkyl, C1-C4 haloalkyl, C1-C4 alkoxy, —CORb1, —CO2Rb1, —SO2Rb1, —SO2NRb1Rb2, and —CONRb1Rb2, wherein each Rb1 and Rb2 is independently selected from the group consisting of H and C1-C4 alkyl or optionally Rb1 and Rb2 when attached to a nitrogen atom are combined to form a 4- to 6-membered ring; andeach Rc is independently selected from the group consisting of halo, hydroxyl and C1-C2 alkoxy. |
