E2F4 SIGNATURE FOR USE IN DIAGNOSING AND TREATING BREAST AND BLADDER CANCER

摘要

Methods for treating breast and bladder cancer patients based upon E2F4 regulatory activity as a predictor of relapse of a patient with estrogen receptor positive breast cancer and in bladder cancer stratification are provided. This invention is a method of administering an aggressive breast cancer treatment (a) providing a ER+ breast tumor tissue sample from a patient; (b) measuring the expression of genes regulated by transcription factor E2F4 in the ER+ breast tumor tissue sample; (c) inferring changes in transcription factor E2F4 activity in the ER+ breast tumor tissue sample using the measured expression in (b); (d) comparing the inferred changes in transcription factor. E2F4 activity in the ER+ breast tumor tissue sample to transcription factor E2F4 activity in a reference sample; and (e) administering an aggressive breast cancer treatment to the patient when the ER+ breast tumor tissue sample has higher transcription factor E2F4 activity than in the reference sample.