ANTIBODIES FOR THE IDENTIFICATION OF PANCREATIC DISORDERS

摘要

Levels of VEGF-A, VEGF-C and PGE2 were measured in patient groups presenting with different types of pancreatic lesions. Pancreatic fluids that exhibited high levels of VEGF-A and relative low levels of VEGF-C correlated well with a diagnosis of serous cystadenoma. Pancreatic fluids collected from cysts in patients that did not have a clinical diagnosis of pancreatic cancer and that exhibited relatively low levels of VEGF-A correlated with a diagnosis of intraductal papillary mucinous neoplasms (IPMN). Furthermore, the level of PGE2 increased with dysplastic stage. Contacting pancreatic fluid with reagents that selectively bind to VEGF-A, VEGF-C and PGE2 provide a useful diagnostic tool for identifying patients with these benign, pre-malignant or malignant lesions of the pancreas.

主权项

1. A method of diagnosing pancreatic lesions, comprising the steps of:
measuring the level of VEGF-A in the sample by contacting the sample with at least one compound that preferentially binds to VEGF-A, wherein the sample is from a patient; determining that the patient, has at least one pancreatic pathology selected from the group consisting of Serous cystadenoma and Cystic adenocarcinoma if the level of VEGF-A measured in the sample is greater than about 7,500 pg ml−1.