PHARMACEUTICAL COMPOSITION COMPRISING NANOG SHRNA, AND METHOD OF USING NANOG SHRNA TO TREAT CANCER

摘要

The present description relates to an inhibitory RNA molecule, comprising an oligonucleotide that selectively knocks down expression a Nanog pseudogene expressed in many human cancers, a replicating viral vector capable of encoding such inhibitory RNA molecule, pharmaceutical compositions comprising said vector, and methods of treating cancer by administration of said pharmaceutical composition.

主权项

1. A conditionally replicating viral vector, comprising an inhibitory RNA molecule comprising an oligonucleotide that knocks down expression of NanogP8 wherein the oligonucleotide comprises a sequence selected from the group consisting of
SEQ ID NO:3 (5′-GAGGCAGCAGAGACCGCTGCATGCACTTCCAGCCA-3′); SEQ ID NO:37 (5′-GAGGCAGCAGAGACCGCTGCATGCAGTTCCAGCCG-3′); SEQ ID NO:8 (5′-TCTGACAGGAAGTGGCTGGAAGTGCATGCAG-3′) and SEQ ID NO:34 (5′-TCTGACAGGAAGTGGCTGGAACTGCATGCAG-3′).