IL-11R BINDING PROTEINS

摘要

The present disclosure provides proteins comprising antigen binding sites of antibodies that bind to interleukin-11 (IL-11) receptor alpha (IL-11Rα) and uses thereof, e.g., in therapy.

主权项

1. An isolated or recombinant IL-11Rα-binding protein comprising an antigen binding domain of an antibody, wherein the antigen binding domain specifically binds to IL-11Rα and neutralizes IL-11 signaling, and the antigen binding domain binds to an epitope comprising residues within the first fibronectin III domain of IL-11Rα, wherein the first fibronectin III domain comprises amino acids 111-215 of SEQ ID NO: 1, and wherein the antigen binding domain comprises a heavy chain variable region (VH) and a light chain variable region (VL), the VL comprising:
(i) a complementarity determining region (CDR) 1 comprising the sequence set forth between amino acids 24-34 of SEQ ID NO: 5 optionally comprising six or fewer amino acid substitutions, a CDR2 comprising the sequence set forth between amino acids 50-56 of SEQ ID NO: 5 and a CDR3 comprising the sequence set forth between amino acids 89-97 of SEQ ID NO: 5 optionally comprising five or fewer amino acid; or (ii) a sequence at least about 94% identical to the sequence set forth in SEQ ID NO: 5.