METHODS AND COMPOSITIONS FOR THE GENERATION AND USE OF CONFORMATION-SPECIFIC ANTIBODIES

摘要

The present invention features methods and compositions for the generation and use of conformation-specific anti-bodies or fragments thereof.

主权项

1. An isolated conformation-specific binding moiety, wherein:
(a) said binding moiety comprises one, two, or more heavy chain variable regions with SEQ ID NOs:1-3, or variants thereof, and one, two, or more light chain variable regions with SEQ ID NOs:4-6, or variants thereof, or (b) said binding moiety comprises one, two, or more heavy chain variable regions with SEQ ID NOs:7-9, or variants thereof, and one, two, or more light chain variable regions with SEQ ID NOs:10-12, or variants thereof.