发明名称 |
2-SUBSTITUTED IMIDAZO[4,5-D]PHENANTHROLINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CANCER |
摘要 |
The present invention provides 2-substituted imidazo[4,5-d]phenanthroline compounds, which are capable of inhibiting proliferation of one or more renal cancer cells, pancreatic cancer cells, prostate cancer cells, colon cancer cells, leukemia cells, brain cancer/tumour cells or non-small cell lung cancer cells. |
申请公布号 |
US2016031883(A1) |
申请公布日期 |
2016.02.04 |
申请号 |
US201414777198 |
申请日期 |
2014.03.20 |
申请人 |
Aptose Biosciences Inc. |
发明人 |
LEE Yoon;CUKIER Howard;NEDUNURI Venkata;PERALTA Robert;HUESCA Mario;YOUNG Aiping H. |
分类号 |
C07D471/14 |
主分类号 |
C07D471/14 |
代理机构 |
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代理人 |
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主权项 |
1. A compound of formula (I): or a salt or solvate thereof, wherein:
between C and X, and between C and Y designates a single or a double bond, and at least one of is a single bond;X is optionally substituted alkoxy or NR3R4 when between C and X is single bond, orX is O when between C and X is a double bond;Y is N when between C and Y is a double bond, or Y is NH, when between C and Y is a single bond;R1 and R2 are independently H, optionally substituted alkyl, or optionally substituted alkoxy, andR3 and R4 are taken together to form a 5 or 6 membered optionally substituted heterocycle, having at least one heteroatom that is N or O; andprovided that when X is O and between C and X is a double bond; then R1 and R2 both are not H. |
地址 |
Toronto CA |