GUANIDINOBENZOIC ACID ESTER COMPOUND

摘要

[Problem]To provide a compound which is useful as an agent for preventing and/or treating kidney diseases.;[Means for Solution]The present inventors have studied compounds having a trypsin inhibitory activity, and have confirmed that a guanidinobenzoic acid ester compound has a trypsin inhibitory activity, thereby completing the present invention. The guanidinobenzoic acid ester compound of the present invention can be used as an agent for preventing and/or treating kidney diseases (for example, chronic kidney disease, acute glomerulonephritis, acute kidney injury, and the like) as an agent which will substitute low-protein diet therapy, and/or as an agent for preventing and/or treating trypsin-related diseases (for example, chronic pancreatitis, gastroesophageal reflux disease, hepatic encephalopathy, influenza, and the like).

主权项

1. A compound of Formula (I) or a salt thereof: wherein L1 is a bond or -lower alkylene-, L2 is an optionally substituted lower alkylene, R1 is H or lower alkyl optionally substituted with at least one substituent selected from the group consisting of an optionally substituted aryl, an optionally substituted aromatic heterocyclic group, and —CO2H, or R1 with the nitrogen atom bonded thereto and the HO2C-L2 group on the nitrogen atom form a cyclic amino optionally substituted with —CO2H, and Ring B is naphthalenediyl, 1,2,3,4-tetrahydronaphthalenediyl, 2,3-dihydroindenediyl, benzothiophenediyl, benzofurandiyl, or 2,3-dihydrobenzofurandiyl.