| 摘要 |
The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same. Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful for treating a variety of diseases, disorders or conditions, associated with abnormal cellular responses triggered by protein kinase-mediated events. Compounds provided by this invention are also useful for the study of kinases in biological and pathological phenoma, the study of intracellular signal transduction pathways mediated by such kinases and the comparative evaluation of new kinase inhibitors. |
| 主权项 |
1. A compound of Formula I:or a pharmaceutically acceptable salt thereof, wherein:
each R1, R2, R3, R3′, R4, R4′, R5, R5′, R6, R6′, R6″, Rxa, Rxb, Rxb′, Rxc, Rya, Rya′, Ryb and Ryb′ is independently selected from hydrogen or deuterium; provided that at least one of R1, R2, R3, R3′, R4, R4′, R5, R5′, R6, R6′, R6″, Rxa, Rxb, Rxb′, Rxc, Rya, Rya′, Ryb and Ryb′ is deuterium. |
