| 主权项 |
1. A method for treating a disease characterized by excessive lipofuscin accumulation in the retina in a mammal afflicted therewith, comprising administering to the mammal an effective amount of a compound having the structure: wherein ring A is benzene optionally further substituted; R1 is an optionally substituted branched C3-6 alkyl group; X1 is an O, S, SO, SO2 or NH; X2 is a bond or a C1-3 alkylene group; ring B is azetidine, pyrrolidine or piperidine; X3 is CO or SO2; R2 is a substituent, provided that (1) when —X1-X2— is —NH— and ring B is piperidine, then X3 is CO; (2) when X3 is CO, then R2 is not a tert-butoxy group, or a salt thereof, or a pharmaceutically acceptable salt thereof. |
