METHODS AND DEVICES FOR MECHANICAL AND ELECTRICAL STIMULATION OF STEM CELL MONOLAYER AND 3D CULTURES FOR TISSUE ENGINEERING APPLICATIONS

摘要

Devices and methods for stimulating mechanically or electromechanically stem cell monolayer and 3D cultures for tissue engineering applications are disclosed. A bracket is proposed to be used in a disposable stimulation device. A disposable stimulation device is also proposed for accommodating a cell culture in a flexible area. Finally, an apparatus is proposed to mechanically extend the disposable stimulation device to induce mechanical stimulation. Additionally, a pair of electrodes placed at two opposing sides of the flexible area creates an electric field to induce electrical stimulation. Accordingly, a method to stimulate electromechanically a cell culture is proposed.

主权项

1. A bracket attachable to a flexible cell culture pool to form a stimulation device, the bracket comprising:
a first portion adapted to accommodate a ferromagnetic element, wherein a first side of the first portion of the bracket is attachable to a side of the flexible cell culture pool.