发明名称 |
USE OF AMINOLEVULINIC ACID AND DERIVATIVES THEREOF |
摘要 |
The invention provides the use of a photosensitiser which is a derivative (e.g. an ester) of 5-aminolevulinic acid (5-ALA), or a pharmaceutically acceptable salt thereof, in the manufacture of a composition for use in methods of photodynamic therapy (PDT) on an animal, wherein said PDT comprises:
(a) administering to said animal a composition comprising said photosensitiser; and(b) photoactivating said photosensitiser,
and side-effects (e.g. pain and/or erythema) of said PDT are prevented or reduced by use of one or more of (i)-(iv):
(i) said composition comprises said photosensitiser in a concentration of less than 10% wt (e.g. 0.5 to 8% wt),(ii) said composition is administered for less than 2 hours (e.g. 30 minutes to 90 minutes) prior to said photoactivation,(iii) said photoactivation is carried out with a light source having a fluence rate of less than 50 mW/cm2 (e.g. 5 to 40 mW/cm2),(iv) said photoactivation is carried out with sunlight.;Preferably, side effects of PDT are prevented or reduced by using (ii) or (iv) in combination with (i) and/or (ii). |
申请公布号 |
US2016030565(A1) |
申请公布日期 |
2016.02.04 |
申请号 |
US201514873566 |
申请日期 |
2015.10.02 |
申请人 |
Photocure ASA |
发明人 |
Wulf Hans Christian;Godal Aslak;Klaveness Jo;Fuglerud Per Harald |
分类号 |
A61K41/00;A61N5/06;A61K31/221 |
主分类号 |
A61K41/00 |
代理机构 |
|
代理人 |
|
主权项 |
1. A method of photodynamic treatment of acne comprising:
(a) administering to an area characterized by acne on a patient in need of such treatment a composition comprising methyl ALA ester at a concentration of 4% to less than 10% by weight of the composition, or the equivalent concentration of a pharmaceutically acceptable salt, for a period of 30 minutes to less than 2 hours, and (b) administering photoactivating light to the area. |
地址 |
Olso NO |