发明名称 |
METHODS AND COMPOSITIONS FOR TREATMENT OF HER-POSITIVE CANCERS |
摘要 |
Cancers that overexpress tyrosine kinase receptors of HER family are treated with drugs acting on these receptors. Although HER-targeting drugs have revolutionized the treatment of HER-positive cancers, high rates of primary and treatment-emergent resistance limit their clinical utility. The present inventors have now discovered that combining HER-targeting drugs with a selective inhibitor of CDK8/19 greatly improves the efficacy of such drugs, offering an improved approach to the treatment of HER-positive cancers. |
申请公布号 |
CA2959762(A1) |
申请公布日期 |
2016.02.04 |
申请号 |
CA20152959762 |
申请日期 |
2015.06.10 |
申请人 |
UNIVERSITY OF SOUTH CAROLINA |
发明人 |
MCDERMOTT, MARTINA;RONINSON, IGOR B.;BROUDE, EUGENIA |
分类号 |
C07D239/94;A61K31/517;A61K31/5377;A61K39/395;C07D403/12 |
主分类号 |
C07D239/94 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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