SYSTEM AND METHOD TO INCREASE THE OVERALL DIAMETER OF VEINS

摘要

A system and method for increasing the speed of blood and wall shear stress (WSS) in a peripheral vein for a sufficient period of time to result in a persistent increase in the overall diameter and lumen diameter of the vein is provided. The method includes pumping blood at a desired rate and pulsatility. The pumping is monitored and adjusted, as necessary, to maintain the desired blood speed, WSS and pulsatility in the peripheral vein in order to optimize the rate and extent of dilation of the peripheral vein.

主权项

1. A system for increasing an overall diameter and a lumen diameter of a peripheral vein prior to creation of an arteriovenous fistula or an arteriovenous graft in a patient comprising:
a pump-conduit assembly to remove deoxygenated blood from a donating vein or the right atrium and pump blood into the peripheral vein, the pump-conduit assembly including:
a pump configured to pump blood, having a pump inlet and a pump outlet;a first conduit configured to carry blood having an inlet configured to fluidly connect to a donating vein or right atrium to remove the deoxygenated blood from the donating vein or to the right atrium, such first conduit comprising a catheter configured for insertion into a vein and advancement within the lumen of the vein, including into the right atrium; and an outlet fluidly connected to the pump inlet;a second conduit configured to carry blood having an inlet fluidly connected to the pump outlet and an outlet to fluidly connect to a peripheral vein, such conduit comprising a first segment comprising a catheter and configured to connect to the pump outlet and a second segment configured to enable the creation of a surgical anastomosis between an end of the second segment and the peripheral vein using the end of the second segment to attach to the side of the peripheral vein; and a control unit to control the pump and pump deoxygenated blood into the peripheral vein at a rate to maintain a mean wall shear stress in the peripheral vein between 1.5 Pa and 23 Pa for a period of 7-84 days.