| 发明名称 |
DITERPENOID MEMBRANOLIDE COMPOUNDS HAVING ANTI-LEISHMANIA ACTIVITY AND USES THEREOF |
| 摘要 |
In a screening program, the Antarctic sponge Dendrilla membranosa was found to produce diterpenoid secondary metabolites with activity against the leishmaniasis-causing parasite Leishmania donovani. The present invention concerns compositions useful for control of Leishmania spp. parasites in vitro and in vivo and treatment of leishmaniasis; methods for treatment of leishmaniasis; and methods for controlling Leishmania spp. parasites in vitro and in vivo. |
| 申请公布号 |
US2016030388(A1) |
申请公布日期 |
2016.02.04 |
| 申请号 |
US201514811341 |
申请日期 |
2015.07.28 |
| 申请人 |
BAKER BILL J.;WITOWSKI CHRISTOPHER G.;MASCHEK JOHN ALAN;VESELY BRIAN;KYLE DENNIS E. |
发明人 |
BAKER BILL J.;WITOWSKI CHRISTOPHER G.;MASCHEK JOHN ALAN;VESELY BRIAN;KYLE DENNIS E. |
| 分类号 |
A61K31/365;A61K45/06;A61K31/343;A61K31/366 |
主分类号 |
A61K31/365 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. A composition comprising an anti-Leishmania agent; and a compound having the following chemical structure: wherein A-B—C is: or A-B is: and C is: or A-B is and C is: or A is: and B—C is: wherein R is H or alkyl, wherein R1 is H and R2 is alkoxyl, or R2 is H and R1 is alkoxyl, and wherein R3 is H and R4 is alkoxyl, or R4 is H and R3 is alkoxyl; or a pharmaceutically acceptable salt thereof. |
| 地址 |
TAMPA FL US |
