USE OF INDOLE COMPOUNDS FOR FAT REDUCTION AND SKIN AND SOFT TISSUE TIGHTENING

摘要

The present invention relates to indole compounds and compositions and uses thereof, including uses of the indole compounds and compositions for the reduction or removal of localized fat deposits and/or tightening of skin and soft tissue laxity in subjects. The indole compounds can be employed, for example, in the cosmetic sector or for producing pharmaceutical products.

主权项

1. A method for non-surgical reduction or removal of one or more localized fat deposits in a subject having localized fat accumulation comprising administering to a target site in the fat deposit a compound of Formula (I): wherein R1 is hydrogen, C1-6 alkyl, hydroxyl, or —(CH2)x—CONH2; R2, R3, R4, R5, R6, and R7 are independently selected from hydrogen, C1-6alkyl, C1-6alkoxy, amino, substituted amino, halogen, heteroaryl, substituted heteroaryl, —(CH2)x—C(O)—OC1-6 alkyl, —(CH2)x—OH, —(CH2)x—CN, —OCH2C6H5, —OCOCH3, —(CH2)x—CONH2, —CHO, —(CH2)x—COOH, —(CH2)x—COOC1-6 alkyl, —(CH2)y—CO—COOH, and —(CH2)y—C(H)(OH)—COOH; or any two adjacent R4, R5, R6, and R7, together with the atoms they attach to, form a five to seven-membered carbocyclic ring; or R2 and R3, together with the atoms they attach to, form an unsubstituted or substituted five to seven-membered heterocyclyl ring; x is a number from zero to six; and y is a number from zero to six; or a pharmaceutically acceptable salt thereof.