| 摘要 |
The present invention provides a pharmaceutical composition for preventing or treating autoimmune diseases, containing human bone marrow-derived mesenchymal stem cells as an active ingredient. The human bone marrow-derived mesenchymal stem cells of the present invention exhibit prophylactic or therapeutic efficacy on autoimmune diseases by having no toxicity, suppressing the generation of anti-dsDNA antibodies, proteinuria, and total IgG, inhibiting the proliferation of T cells and B cells, and inhibiting cytokine expression of T cells. Lupus causes inflammation in the kidney by autoantibodies and immune complexes, and increases the infiltration of immune cells, and the administration of the human bone marrow-derived mesenchymal stem cells of the present invention reduces the infiltration of immune cells into the kidney, thereby exhibiting a prophylactic or therapeutic effect on the lupus. |
