TOLEROGENIC SYNTHETIC NANOCARRIERS FOR GENERATING CD8+ REGULATORY T CELLS

摘要

Disclosed are synthetic nanocarrier methods, and related compositions, comprising administering MHC Class I-restricted and/or MHC Class II-restricted epitopes of an antigen and immunosuppressants in order to generate tolerogenic immune responses against the antigen, such as the generation of antigen-specific CD8+ regulatory T cells.

主权项

1. A method comprising:
(A) administering to a subject a composition that comprises: (i) a first population of synthetic nanocarriers coupled to immunosuppressants, and (ii) MHC Class I-restricted and/or MHC Class II-restricted epitopes of an antigen, wherein the composition is in an amount effective to generate antigen-specific CD8+ regulatory T cells in the subject; or (B) generating antigen-specific CD8+ regulatory T cells in a subject by administering a composition that comprises: (i) a first population of synthetic nanocarriers coupled to immunosuppressants, and (ii) MHC Class I-restricted and/or MHC Class II-restricted of an antigen; or (C) administering to a subject a composition according to a protocol that was previously shown to generate antigen-specific CD8+ regulatory T cells in one or more test subjects; wherein the composition comprises: (i) a first population of synthetic nanocarriers coupled to immunosuppressants, and (ii) MHC Class I-restricted and/or MHC Class II-restricted epitopes of an antigen.