发明名称 IL-18 INHIBITION FOR PROMOTION OF EARLY HEMATOPOIETIC PROGENITOR EXPANSION
摘要 Disclosed herein are methods for enhancing hematopoietic reconstitution of a subject. One method involves administering a therapeutically effective amount of an inhibitor of IL-18 to a recipient subject and also administering hematopoietic stem/progenitor cells to the subject. Another method involves administering an inhibitor of IL-18 to a donor prior to harvest of hematopoietic stem/progenitor cells. Pharmaceutical compositions relating to the methods are also described.
申请公布号 US2016030481(A1) 申请公布日期 2016.02.04
申请号 US201414760076 申请日期 2014.01.14
申请人 THE GENERAL HOSPITAL CORPORATION ;PRESIDENT AND FELLOWS OF HARVARD COLLEGE 发明人 SCADDEN David T.;SILBERSTEIN Lev;KHARCHENKO Peter
分类号 A61K35/28;A61K38/17 主分类号 A61K35/28
代理机构 代理人
主权项 1. A method for enhancing hematopoietic reconstitution of a subject in need thereof comprising: a) administering to the subject hematopoietic stem/progenitor cells (HSPC); and b) administering to the subject a therapeutically effective amount of an inhibitor of interleukin 18 (IL-18) to thereby inhibit IL-18 interaction with IL-18R molecules present on the HSPC administered in step a).
地址 Boston MA US