发明名称 |
IL-18 INHIBITION FOR PROMOTION OF EARLY HEMATOPOIETIC PROGENITOR EXPANSION |
摘要 |
Disclosed herein are methods for enhancing hematopoietic reconstitution of a subject. One method involves administering a therapeutically effective amount of an inhibitor of IL-18 to a recipient subject and also administering hematopoietic stem/progenitor cells to the subject. Another method involves administering an inhibitor of IL-18 to a donor prior to harvest of hematopoietic stem/progenitor cells. Pharmaceutical compositions relating to the methods are also described. |
申请公布号 |
US2016030481(A1) |
申请公布日期 |
2016.02.04 |
申请号 |
US201414760076 |
申请日期 |
2014.01.14 |
申请人 |
THE GENERAL HOSPITAL CORPORATION ;PRESIDENT AND FELLOWS OF HARVARD COLLEGE |
发明人 |
SCADDEN David T.;SILBERSTEIN Lev;KHARCHENKO Peter |
分类号 |
A61K35/28;A61K38/17 |
主分类号 |
A61K35/28 |
代理机构 |
|
代理人 |
|
主权项 |
1. A method for enhancing hematopoietic reconstitution of a subject in need thereof comprising:
a) administering to the subject hematopoietic stem/progenitor cells (HSPC); and b) administering to the subject a therapeutically effective amount of an inhibitor of interleukin 18 (IL-18) to thereby inhibit IL-18 interaction with IL-18R molecules present on the HSPC administered in step a). |
地址 |
Boston MA US |