MODIFIED T LYMPHOCYTES

摘要

Provided herein are cells, e.g., T cells expressing artificial cell death polypeptides that cause death of a cell, e.g., cells (e.g., T lymphocytes) expressing the cell death polypeptide, when the cell death polypeptide is multimerized or dimerized. Also provided herein is use of such cells, e.g., T lymphocytes, to treat diseases such as cancer.

主权项

1. A T lymphocyte comprising an artificial cell death polypeptide comprising an apoptosis-inducing domain, wherein said polypeptide is multimerizable using a multimerizing agent, wherein said multimerizing agent is not an FK506 binding protein (FKBP) ligand, and wherein when said multimerizing agent multimerizes said polypeptide, an apoptosis-inducing signal is generated in said T lymphocyte.